Inert LC System

Inert LC System

A new inert LC system is now part of Prominence series. Featuring the same high reliability, robustness, and expandability as the Prominence series, this system is ideal for the analysis of biopolymers such as antibody drugs.

Stable Data

The Prominence inert LC system employs non-metallic materials such as PEEK resin in the liquid contact parts for the mobile phase and sample solution. It not only enables high concentration salts and acids to be used in the mobile phase, but it also suppresses the adsorption of samples with high affinity to metals.

The newly designed LC-20Ai solvent delivery unit offers highly reproducible analyses due to an extremely accurate liquid delivery capability.

Analysis of Monoclonal Antibody Aggregates

Normally, it is difficult to achieve stable results with HPLC for the aggregate analysis of antibody drugs because of the high concentrations of salt, such as sodium chloride, used in the mobile phase. In contract, with its metal-free design, the Prominence inert system enables stable aggregate analysis.

Size Exclusion Chromatography Analysis of Protein Standards

SEC Chromatogram of Protein Standard Sample

Calibration Curve

 ■ Components

1 : Thyroglobulin (669 kDa)
 2 : Apoferritin (443 kDa)
 3 : -Amylase (200 kDa)
 4 : Alcohol dehydrogenase (150 kDa)
 5 : Albumin (66 kDa)
 6 : Carbonic anhydrase (29 kDa)
 7 : Myoglobin (18 kDa)

For Research Use Only. Not for use in diagnostic procedures.

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